METHOD OF SYNTHESIS OF 1-[[[5-(4-CHLOROPHENYL)-2-FURANYL]METHYLENE]AMINO]- 3-[4-(4-METHYL-1-PIPERAZINYL)BUTYL]-2,4-IMIDAZOLIDINEDIONE DIHYDROCHLORIDE Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to method of synthesis of 1-[[[5-(4- chlorophenyl)-2-furanyl] methylene] -amino] -3-[4-(4-methyl-1-piperazinyl)butyl] -2,4-imidazolidinedione dihydrochloride used as antifibrillary and anti-arrhythmic agent of the general formula: that involves stages: a) interaction of 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione of the formula: with reagent with carbon chain taken among 1-bromo-4-chlorobutane, 1,4-dichlorobutane, 1,4-dibromobutane and their mixtures in the presence of weak base taken among group comprising potassium carbonate, sodium carbonate, potassium hydrocarbonate, sodium hydrocarbonate and polar aprotonic solvent to form 3-N- -alkylated 2,4-imidazolidinedione; and b) interaction of indicated crude 3-N-alkylated 2,4- imidazolidinedione with 4-methylpiperazine to form 1-[[[5-94-chlorophenyl)-2-furanyl] methylene] amino]-3- ]4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione. EFFECT: improved method of synthesis, increased yield, enhanced purity of end product. 15 cl, 4 ex