FIELD: organic chemistry and technology, pharmacy. SUBSTANCE: invention describes novel derivatives of substituted 1-(7-chloroquinoline- -4-yl)-pyrazole-3-carboxamide-N-oxides of the formula (I) 
where T means hydrogen atom, C1-C4-alkyl, C3-C8-cycloalkyl, (C3-C8)- -cycloalkylmethyl, methoxyethyl; group -NH-AA(OH) is amino acid residue of the formula: 
where X means hydrogen atom, C1-C5-alkyl or C3-C15-nonaromatic carbocyclic radical and X' means hydrogen atom; or X and X' in common with carbon atom to which they bound form C3-C15-nonaromatic carbocycle, and their salts. Compounds show high affinity degree to neurotension receptors. Invention describes also method of their synthesis, intermediate compounds and pharmaceutical composition based on compounds of the general formula (I). EFFECT: improved method of synthesis, valuable pharmacological properties. 7 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 1-NAPHTHYLPYRAZOLE-3-CARBOXAMIDES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND INTERMEDIATE COMPOUNDS OF SYNTHESIS | 1994 |
|
RU2140912C1 |
| DERIVATIVES OF PYRAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND INTERMEDIATE COMPOUNDS OF SYNTHESIS | 1993 |
|
RU2119917C1 |
| AZAINDOL DERIVATIVES AS FACTOR Xa INHIBITORS | 2004 |
|
RU2330853C2 |
| BI- AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES, USEFUL AS RHO-KINASE INHIBITORS | 2009 |
|
RU2532481C2 |
| NOVEL DERIVATIVES OF IMIDAZOLIDINE, THEIR PREPARING AND USING AS VLA-4 ANTAGONIST | 2002 |
|
RU2318815C2 |
| PYRAZOLOPYRIDINE DERIVATIVES AS KINASE 1β-ADRENERGIC RECEPTOR INHIBITORS | 2006 |
|
RU2415855C2 |
| PIPERADINYL-SUBSTITUTED ISOQUINOLONE DERIVATIVES AS Rho-KINASE INHIBITORS | 2006 |
|
RU2414467C2 |
| DERIVATIVES OF GLYCINEAMIDE, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2130923C1 |
| SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES AS Rho-KINASE INHIBITORS | 2007 |
|
RU2455302C2 |
| A CONJUGATE CONTAINING A NEUROTENSIN RECEPTOR LIGAND AND ITS APPLICATION | 2015 |
|
RU2743781C2 |
