PYRROLIDINYL DERIVATIVES OF HYDROXAMIC ACID, METHOD OF PREPARATION THEREOF, INTERMEDIATES, METHOD OF PREPARATION THEREOF (VERSIONS), METHOD OF TREATMENT Russian patent published in 2000 - IPC

Abstract RU 2144917 C1

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides new compounds of formula I: (I) and their pharmaceutically acceptable salts where A is hydrogen, hydroxyl, or group OY, in which Y is hydroxyl-protection group; Ar is phenyl optionally specified by one or several substituents selected from halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, CF3, and C1-C4-alkoxy-C1-C4- alkoxy; X is phenyl, naphthyl, biphenyl, benzofuranyl, benzothienyl, 1- tetralon-6yl, C1-C4-flkylenedioxy, or pyridyl, indicated radicals optionally substituted by one to three substituents (halogen, C1-C4-alkyl, C1-C4-alkoxy, hydroxy, nitro, trifluoromethyl, or methylsulfonyl); and R is hydrogen, C1-C4-alkyl, or a hydroxyl-protection group. Compounds I and pharmaceutical compositions containing thereof are appropriate as analgetics, antiinflammatory agents, diuretics, anesthetics, and neuroprotective agents, and also as remedies for treating sudden or functional intestinal disorders such as abdominal pain. Invention also provides methods for preparing hydroxamic acid derivatives (I) and their intermediates (II) . EFFECT: extended choice of various-destination drugs. 12 cl, 1 tbl, 52 ex

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RU 2 144 917 C1

Authors

Fumitaka Ito

Dates

2000-01-27Published

1996-03-28Filed