FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides new compounds of formula I: (I) and their pharmaceutically acceptable salts where A is hydrogen, hydroxyl, or group OY, in which Y is hydroxyl-protection group; Ar is phenyl optionally specified by one or several substituents selected from halogen, hydroxy, C1-C4-alkyl, C1-C4-alkoxy, CF3, and C1-C4-alkoxy-C1-C4- alkoxy; X is phenyl, naphthyl, biphenyl, benzofuranyl, benzothienyl, 1- tetralon-6yl, C1-C4-flkylenedioxy, or pyridyl, indicated radicals optionally substituted by one to three substituents (halogen, C1-C4-alkyl, C1-C4-alkoxy, hydroxy, nitro, trifluoromethyl, or methylsulfonyl); and R is hydrogen, C1-C4-alkyl, or a hydroxyl-protection group. Compounds I and pharmaceutical compositions containing thereof are appropriate as analgetics, antiinflammatory agents, diuretics, anesthetics, and neuroprotective agents, and also as remedies for treating sudden or functional intestinal disorders such as abdominal pain. Invention also provides methods for preparing hydroxamic acid derivatives (I) and their intermediates (II) . EFFECT: extended choice of various-destination drugs. 12 cl, 1 tbl, 52 ex
Authors
Dates
2000-01-27—Published
1996-03-28—Filed