SUBSTITUTED BENZYLAMINOPIPERIDINES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I) and their pharmaceutically acceptable salts where substitute R means halogen-C₁-C₈-alkyl, halogen-C₂-C₈-alkenyl, halogen-C₂-C₈-alkynyl or halogen-C₁-C₈-alkyl substituted with hydroxy- or C₁-C₈-alkoxy-group; R¹ means hydrogen atom, halogen atom or C₁-C₈-alkoxy-group; or R and R¹ in common with two carbon atoms that are common for benzene ring form condensed C₄-C₆-cycloalkyl where one carbon atom is optionally replaced for oxygen atom and where one or two carbon atoms have optionally up to five substituents taken among: halogen atom, C₁-C₆-alkyl and halogen-C₁-C₆-alkyl; X means C₁-C₆-alkoxy-, halogen-C₁-C₆-alkoxy-, phenoxy-group or halogen atom; Ar means phenyl group optionally substituted with halogen atom. These compounds can be used for treatment of gastroenteric disorder, central nervous system disorder, inflammatory disease, vomiting and others. EFFECT: valuable medicinal properties of compounds. 20 cl, 4 tbl, 21 ex