IONIC CONJUGATE EXHIBITING PROLONGED PERIOD OF PEPTIDE RELEASE, METHOD OF SYNTHESIS OF IONIC CONJUGATE, METHOD OF SYNTHESIS OF MICROPARTICLES Russian patent published in 2000 - IPC

Abstract RU 2146128 C1

FIELD: medicine, peptides. SUBSTANCE: invention describes the conjugate of delayed release that involves complex polyester containing free COOH-group coupled with bioactive polypeptide containing at least one effective ionogenic amine being at least 50 weight % of polypeptide in the conjugate composition are coupled with complex polyester. Invention proposes the method of synthesis of ionic conjugate by ionic coupling and the method of synthesis of microparticles by dissolving ionic conjugate by p. 1 of the invention claim in aprotonic water-soluble organic solvent. Conjugate provides the controlled monophase release of biologically active polypeptide molecule in the body. EFFECT: improved properties, enhanced effectiveness of conjugate. 29 cl, 6 tbl, 3 dwg, 11 ex

Similar patents RU2146128C1

Title	Year	Author	Number
POLYESTER AND POLYESTER-BASE CONJUGATE	1994	Shalabi Shalabi V. Dzhehkson Stiven A. Moro Zhak-P'Er	RU2185393C2
IONIC MOLECULAR CONJUGATES OF BIODEGRADABLE COMPLEX POLYESTERS AND BIOACTIVE POLYPEPTIDES	2000	Shelebi Shelebi V. Dzhekson Stiven A. Moro Zhak-P'Er	RU2237681C2
METHOD OF PREPARING IONIC CONJUGATE MICROPARTICLE WITH CONTINUOUS RELEASE, METHOD OF MAKING SPHERICAL FORM FOR IONIC CONJUGATE OF CONTINUOUS RELEASE	1997	Ignejshes Frehnsis Lafmen Tomas Sajehren Shehlabi Shehlabi U. Turo Frank Zhan-Klod	RU2173137C2
BIODEGRADABLE POLYESTER AND METHOD OF PREPARATION THEREOF (VARIANTS)	1997	Lafmen Tomas Sajehren Rassel Rus Mehri Turo Frank Zhan-Klod	RU2165942C2
METHOD FOR PREPARING COMPOSITE WITH DELAYED RELEASE OF ACTIVE COMPONENT	2000	Luman Tomas Siaran	RU2211694C1
PHOSPHORYLATED POLYMERS AND THEIR CONJUGATES	1999	Shalabi Shalabi Vakhba Korbett Dzhoel Tomas	RU2202563C2
MICROPARTICLES CONTAINING PEPTIDE SALTS WITH POLYESTERS WITH TERMINAL CARBOXY-GROUPS AND COMPOSITION CONTAINING THEREOF	1993	Khatchinson Frehnsis Goulehnd	RU2152225C1
PHARMACEUTICAL COMPOSITION WITH IMPROVED STABILITY	2015	Li Yukhua Guarino Endryu Dzh.	RU2728786C2
POLYMERS CAPABLE OF RECOVERY AND REVERSIBLE THERMAL GEL-FORMATION	2010	Fovers Kirk D. Rati Ramesh P'Jao Aj-Zhi	RU2565668C2
BIODEGRADABLE THREE-BLOCK POLYESTER/POLYETHYLENE GLYCOL COPOLYMERS POSSESSING LOW MOLECULAR MASS AND REVERSIBLE THERMAL GELLING PROPERTIES	1999	Rasi Ramesh K. Zentner Gejlen M. Dzheong B'Eongmun	RU2232779C2

RU 2 146 128 C1

Authors

Shalabi V.Shalabi

Stiven A.Dzhehkson

Zhak-P'Er Moro

Dates

2000-03-10—Published

1994-01-05—Filed