METHOD OF PREPARING 4A,5,9,10,11,12-HEXAHYDRO-6H- BENZOFURO (3A,3,2-ef/2/BENZAZEPINE DERIVATIVES AND INTERMEDIATE COMPOUNDS Russian patent published in 2000 - IPC

FIELD: chemical industry. SUBSTANCE: described is method of preparing new 4a, 5,9,10,11,12-hexahydro-6H-benzofuro (3a,3,2-ef (2) benzazepine derivatives of general formula selected from group consisting of and or salts thereof wherein substituents are as defined in claim 1. Method comprises reacting (R₂O)₂C₆H₂(CHO)(X₁) of formula III with compound of formula IV. The resulting condensation product is reduced, cyclized and is made to react with base and oxidizer. The resulting compound of general formula I wherein Y₁ and Y₂ are together=0 (ketone), reduced with L- selectride, K-selectride, KS-selectride and LS-selectride to compound of general formula I wherein Y₁ is hydroxy, and racemic compound of general formula I wherein R₄ is selected from group consisting of hydrogen, lower alkyl or aralkyl, is separated by crystallization by means of chiral acid to corresponding enantiomers. EFFECT: large amounts of the title compounds with higher yields both individual stages and in entire process. 28 cl, 40 ex