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(19)

(11)

2 776 846

(13)

(51)

IPC

A61K31/437(2006-01-01)

A61K31/4375(2006-01-01)

A61K31/444(2006-01-01)

A61K31/4523(2006-01-01)

A61K31/4985(2006-01-01)

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

C07D491/48(2006-01-01)

C07D491/52(2006-01-01)

C07D491/107(2006-01-01)

C07D498/04(2006-01-01)

C07D513/04(2006-01-01)

C07D519/00(2006-01-01)

A61P35/00(2006-01-01)

A61P35/02(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2019126456, 2018-01-09

(24)

Start date

2018-01-09

(22)

Actual filing date

2018-01-09

(45)

Published

2022-07-27

(72)

Inventor

Blank, Brian R.Pitzen, JenniferWang, GangWon, Walter S.Tzitzilonis, ChristosLi, Jie JackKoltun, Elena S.Aay, NaingBuckl, AndreasMellem, KevinSemko, ChristopherJogalekar, AshKiss, GertGill, Adrian

(73)

Holder

Revolution Medicines, Inc.

BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS Russian patent published in 2022 - IPC A61K31/437 A61K31/4375 A61K31/444 A61K31/4523 A61K31/4985 C07D471/04 C07D487/04 C07D491/48 C07D491/52 C07D491/107 C07D498/04 C07D513/04 C07D519/00 A61P35/00 A61P35/02 A61P43/00

Abstract RU 2776846 C2

FIELD: medicine.

SUBSTANCE: invention is aimed at SHP2 inhibitors and their use in the treatment of diseases. Pharmaceutical compositions containing these inhibitors are also disclosed.

EFFECT: obtaining compounds for the treatment of diseases.

72 cl, 1 tbl, 52 ex

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RU 2 776 846 C2

Authors

Blank, Brian R.

Pitzen, Jennifer

Wang, Gang

Won, Walter S.

Tzitzilonis, Christos

Li, Jie Jack

Koltun, Elena S.

Aay, Naing

Buckl, Andreas

Mellem, Kevin

Semko, Christopher

Jogalekar, Ash

Kiss, Gert

Gill, Adrian

Dates

2022-07-27—Published

2018-01-09—Filed