METHOD OF PRODUCING CANDESARTAN Russian patent published in 2010 - IPC C07D403/10 C07D235/26 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing candesartan or a protected form of candesartan, candesartan salt or candesartan ester using a catalyst or several catalysts preferably containing one or more transition metals, and one or more of the following solvents: tetrahydrofuran (THF), THF/NMP (N-methylpyrrolidone), Et₂O, DME (dimethoxy ethane), benzene, toluene, involving the following steps: (a) supply and reaction of a compound of formula (I), where R denotes hydrogen, unsubstituted or substituted alkyl or aryl radical, preferably methyl or (cyclohexyloxycarbonyloxy)ethyl, Y¹ denotes a group capable of a coupling reaction into which Y² comes in to form a C-C bond, with a compound of formula (II), having group Y², where R¹ is selected from a group comprising hydrogen, tert. Butyl and triphenylmethyl, preferably triphenylmethyl, to form candesartan, a protected form of candesartan or candesartan ester or candesartan cilexetil or some other candesartan ester, where (i) Y¹ denotes B(OR⁴)₂, where each of the radicals R⁴ independently denotes hydrogen, alkyl, aryl or alkylaryl, preferably hydrogen, and Y² denotes a halogen, preferably bromine, or (and) Y denotes a halogen, preferably bromine,and Y² denotes B(OR⁴)₂, where each of radicals R⁴ independently denotes hydrogen, alkyl, aryl or alkylaryl, preferably hydrogen, and if necessary, (b) conversion to candesartan, candesartan cilexetil or salt.

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EFFECT: novel method for producing candesartan with high output.

24 cl, 3 dwg, 1 tbl, 9 ex