FIELD: natural organic compounds, oncology. SUBSTANCE: invention describes new fluorotaxols of the formula (I) 
where: R1 means -COR2 where R2 is RO- or R; R9 means C2-6-alkenyl or a radical of the formula W-Rx where W is a bond and Rx means furyl, thienyl or phenyl; R2 means -OCOR, H, OH, -OR, -OSO2R, -OCOO(CH2)tR, or -OCOOR where t is a whole number from 1 to 6 and R means independently C1-6-alkyl or phenyl. Invention describes intermediate compounds, a pharmaceutical composition showing an antitumor activity on the basis of compounds of the formula (I) and a method of treatment of mammals with tumors using the above indicated compounds. EFFECT: new antitumor compounds. 13 cl, 7 dwg, 2 tbl, 36 ex
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Year |
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| 7-DEOXYDERIVATIVES OF TAXOL, DERIVATIVES OF BACCATINE, 10-PENTAFLUOROPHENYLBACCATINE, 7-[(METHYLTHIO)CARBONOTHIOYLHYD- -ROXY]-13-TRIETHYLSILYLHYDROXYBACCATINE, PHARMACEUTICAL COMPOSITION |
1993 |
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1996 |
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