FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of 3H-2,3-benzodiazepine of the general formula (I) 
where values R1-R7 and n are given in p. 1 of the invention claim and their physiologically tolerated salts showing AMPA-antagonistic activity also. They can be used as drug in compositions for treatments of patients with neurological and psychiatric disorders, for example, Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and others. Invention describes also the method of their synthesis and pharmaceutical composition based on said. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 6 cl, 3 tbl, 53 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF 2,3-BENZODIAZEPINE, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND AGENT ELICITING INHIBITORY ACTIVITY WITH RESPECT TO AMPA-RECEPTORS | 1997 |
|
RU2179557C2 |
| DERIVATIVES OF 2,3-BENZODIAZEPINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT | 2000 |
|
RU2243228C2 |
| METHODS OF SYNTHESIS IF DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES AND INTERMEDIATE COMPOUNDS | 1995 |
|
RU2151149C1 |
| DERIVATIVES OF 8-SUBSTITUTED=9H-1,3-DIOXOL[4,5-H][2,3]- BENZODIAZEPINE AS INHIBITORS OF AMPA/KAINATE RECEPTOR, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT | 1998 |
|
RU2208013C2 |
| ANELATED BETTA-CARBOLINES | 1996 |
|
RU2169148C2 |
| DIHYDROBENZODIAZEPINES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2247115C2 |
| DERIVATIVES OF 1,3-DIOXOL[4,5-H][2,3]BENZODIAZEPINE AS INHIBITORS OF AMPA/KAINATE RECEPTOR, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT | 1998 |
|
RU2208014C2 |
| DERIVATIVES OF QUINOXALINEDIONE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL AGENT BASED ON SAID | 1994 |
|
RU2140420C1 |
| 17-DIFLUOROMETHYLENE-EXTRATRIENES: COMPOUNDS AND METHOD OF PREPARATION THEREOF | 1996 |
|
RU2155770C2 |
| DERIVATIVES OF PYRIDO[1,2,3-DE]QUINOXALINE, METHODS OF THEIR SYNTHESIS, DRUG | 1994 |
|
RU2140924C1 |
