FIELD: organic chemistry, medicine, neurology, pharmacy. SUBSTANCE: invention relates to novel derivatives of 8-substituted-9H-1,3-dioxol[4,5-h] [2,3] benzodiazepine of the formula (I) 
, method for preparing these compounds and pharmaceutical compositions comprising these active substances. Compounds of the formula (I) inhibit AMPA/kainate receptors. In compound of the formula (I) X means carbonyl or methylene group; Y means hydrogen atom or methyl group or in common with R3 it forms valence bond; R1-R3 mean values as given in the invention claim. Invention relates also to method of treatment of patients with epilepsy or neurodegenerative diseases. Invention provides preparing novel compounds eliciting the curative effect that allows to use them in medicine. EFFECT: improved preparing method, valuable medicinal properties of compounds and composition. 13 cl, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF 1,3-DIOXOL[4,5-H][2,3]BENZODIAZEPINE AS INHIBITORS OF AMPA/KAINATE RECEPTOR, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT | 1998 |
|
RU2208014C2 |
| DERIVATIVES OF 2,3-BENZODIAZEPINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT | 2000 |
|
RU2243228C2 |
| DERIVATIVES OF 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND INTERMEDIATE COMPOUND | 1998 |
|
RU2180903C2 |
| NOVEL DIHYDRO-OXAZOLOBENZODIAZEPINE COMPOUNDS, METHOD OF OBTAINING THEREOF AND THEREOF-CONTAINING PHARMACEUTICAL COMPOSITIONS | 2012 |
|
RU2572556C2 |
| DERIVATIVES OF 2,3-BENZODIAZEPINE, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND AGENT ELICITING INHIBITORY ACTIVITY WITH RESPECT TO AMPA-RECEPTORS | 1997 |
|
RU2179557C2 |
| DERIVATIVES OF 1-[2-(SUBSTITUTED VINYL)]-5H-2,3-BENZODIAZEPINE, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING, METHOD OF TREATMENT OF PATIENTS WITH CENTRAL NERVOUS SYSTEM DISEASE | 1996 |
|
RU2161607C2 |
| DERIVATIVES OF 1,2,4-TRIAZOLYLTHIOAMIDES | 1990 |
|
RU2045521C1 |
| 3-SUBSTITUTED DERIVATIVES OF 3H-2,3-BENZODIAZEPINE, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2146678C1 |
| DERIVATIVES OF 1-[2-(SUBSTITUTED VINYL)]-3,4-DIHYDRO-5H-2,3-BENZODIAZEPINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF PREPARING PHARMACEUTICAL COMPOSITION AND METHOD OF SUPPRESSION OF CONVULSIONS | 1996 |
|
RU2155757C2 |
| DIHYDROPYRIMIDOTHIAZINE DERIVATIVES OR THEIR THERAPEUTICALLY ACCEPTABLE SALTS OF ACID BINDING SHOWING ANTIANGINAL AND ANTIINFLAMMATORY ACTIVITY | 1990 |
|
RU2022965C1 |
