FIELD: molecular biology, medicinal genetics. SUBSTANCE: method involves hybridization of short oligonucleotide probe (length is 4-6 links) having flanking oligonucleotide sequences or their derivatives carrying polycyclic aromatic groups with complementary analyzed sequence of nucleic acids. Sequence can has point mutations. Mutation to be determined must be in site of probe binding. Invention can be used for diagnosis of genetic diseases and ensures to perform the high-selective diagnosis of diseases based on alternations of nucleic acid structure. EFFECT: improved method of detection. 3 cl, 1 tbl, 18 ex
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