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2 148 056

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IPC

(21) (22)

Application

95109936/04, 1993-10-26

(24)

Start date

1993-10-26

(22)

Actual filing date

1993-10-26

(45)

Published

2000-04-27

(72)

Inventor

Dzhejms P.DokhertiKonrad P.DornFilip L.DjurePol Eh.FinkMal'Kom MakkossSander G.MillsShrenik K.ShakhSoumia P.SakhooDzheffri Dzh.KhejlTomas Dzh.LanzaUil'Jam K.Khagmann

(73)

Holder

Merk Ehnd Ko., Ink.

SUBSTITUTED AZETHIDINONES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT Russian patent published in 2000 - IPC

Abstract RU 2148056 C1

FIELD: organic chemistry, medicine, pharmacy, biochemistry. SUBSTANCE: invention relates to substituted azethidinones of the general formula (I) given in description. Compound of the formula (I) is synthesized by interaction of compound of the formula (II) with H-Y -NR₇R₈-. Compound of the formula (I) is a powerful inhibitor of human leukocyte elastase activity and can be used as anti-inflammatory and antidegenerative agent. EFFECT: improved method of synthesis, valuable pharmacological properties of compound. 33 cl, 10 tbl, 2 dwg, 26 ex

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RU 2 148 056 C1

Authors

Dzhejms P.Dokherti

Konrad P.Dorn

Filip L.Djure

Pol Eh.Fink

Mal'Kom Makkoss

Sander G.Mills

Shrenik K.Shakh

Soumia P.Sakhoo

Dzheffri Dzh.Khejl

Tomas Dzh.Lanza

Uil'Jam K.Khagmann

Dates

2000-04-27—Published

1993-10-26—Filed