FIELD: biotechnology, medicine, peptides. SUBSTANCE: invention relates to compounds of the general formula R1-X-R2 where X means nonpeptide polymeric spacer and R1 and R2 are antagonist of interleukin-1 receptors or inhibitor of tumor necrosis factor. Compounds are synthesized by interaction of R1 and R2 containing or modified so that they have reactive cysteine with nonpeptide spacer which is able to form thioester bonds. Muteins are obtained by recombinant technology. EFFECT: decreased rate of elimination of therapeutic agent from body. 36 cl, 24 dwg, 4 tbl, 19 ex
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