FIELD: organic chemistry. SUBSTANCE: invention describes the novel sulfonamides of the general formula (I) 
where values Ar2, R1, R2 are given in p. 1 of the invention claim that can be used for inhibition of binding endothelin peptide with endothelin receptors in contact of receptors with sulfonamide. Invention describes also methods of treatment of endothelin-dependent diseases, method of inhibition of binding endothelin peptide with endothelinA-(ETA) or B-(ETB) receptors and method of modulation of activity inducing by endothelin receptors and pharmaceutical composition based on compounds of the formula (I). EFFECT: new sulfonamides indicated above, improved method of treatment and inhibition. 127 cl, 13 tbl, 445 ex
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