QUINAZOLINE DERIVATIVES AS INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) Russian patent published in 2007 - IPC C07D401/12 A61K31/517 A61P35/00

Abstract RU 2291868 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of quinazoline of the formula (I): m means a whole number from 1 to 3; R¹ represents halogen atom or (C₁-C₃)-alkyl; X¹ represents -O-; R² represents (C₁-C₅)-alkyl-R³ wherein R³ represents piperidine-4-yl that can comprise one or two substitutes chosen from (C₁-C₄)-alkyl and to their salts. Also, invention relates to methods for synthesis of these compounds and pharmaceutical compositions comprising compound of the formula (I) or its pharmaceutically acceptable salts as an active component. Compounds of the formula (I) and their pharmaceutically acceptable salts inhibit effect of VEGF that is a valuable property in treatment of different pathological states including cancer and rheumatic arthritis.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

28 cl, 14 ex

Similar patents RU2291868C2

Title	Year	Author	Number
NOVEL AMIDE DERIVATIVE FOR INHIBITING GROWTH OF CANCER CELLS	2008	Li Kvang-Ok Cha Mi Joung Kim Mi Ra Dzung Joung Khee Li Chang Gon Kim Se Joung Bang Keukchan Park Bum Voo Choi Bo Im Chae Jun Dzung Ko Mi Joung Kim Khan Kiong Akhn Joung-Gil Kim Maeng Sup Li Gvan Sun	RU2434010C2
METHOD OF PRODUCING 4-(4-BROMO-2-FLUOROANILINO)-6-METHOXY-7(1-METHYLPIPERIDIN-4YLMETHOXY)QUINAZOLINE (ZD6474) AND METHODS OF PRODUCING INTERMEDIATE COMPOUNDS FOR PRODUCING SAID COMPOUND	2006	Blikst Jergen Golden Majkl Dejvid Khougan Filip Dzhon Martin Dejvid Majkl Glanvill Montgomeri Fransis Dzhozef Pejtel Zakarija Pittam Dzhon Dejvid Sipenda Dzhordzh Dzhozef Skvajer Kristofer Dzhon Rajt Nikolas Kartrajt Aleksander	RU2448102C2
QUINAZOLINE DERIVATIVES	2015	Shi Jing Gao Kingzkhi Chen Ksiaozuo Mi Ji Zang Jaran Yang Khanyu Chen Yudzhi Liu Chunlej Mi Guoruj Ma Yuksiu Shen Dongmin Guo Yang Fan Lindzhing	RU2704125C2
QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF VESSEL ENDOTHELIUM GROWTH FACTOR	1997	Tomas Ehndrju Peter Dzhonstoun Krehjg Ehnnekehn Loran Fransua Andre	RU2196137C2
QUINAZOLINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND A METHOD FOR REACHING ANTIPROLIFERATIVE EFFECTS	1996	Kejt Khopkinson Gibson	RU2153495C2
DERIVATIVES OF QUINAZOLINE AS INHIBITORS OF ANGIOGENESIS	2000	Ehnnekehn Loran Fransua Andre Ple Patrik Stouks Ehlejn Sofi Ehlizabet Makkerrecher Darren	RU2262935C2
DERIVATIVES OF QUINAZOLINE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF, METHOD OF ATTAINMENT OF ANTIANGIOGENIC EFFECT AND/OR EFFECT OF BLOOD VESSEL PERMEABILITY REDUCTION IN WARM-BLOODED ANIMAL	1997	Tomas Ehndrju Piter Ehnneken Loran Fransua Andre Dzhonstoun Krejg Stouks Ehlejn Sofi Ehlizabet Loman Zhan-Zhak Marsel' Klehjton Ehdvard	RU2198879C2
SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST, METHOD OF ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING IT AS AN ACTIVE INGREDIENT	2020	Paek Seung Yup Park Deok Seong Hong Sang Yong	RU2798605C1
2-AMINO-4-PHENYL-4-OXOBUTYRIC DERIVATIVES ACID AND PHARMACEUTICAL COMPOSITION	1994	Mario Virazi Antonio Dzhiordani Karmela Spechiale Massimo Chini Al'Berto B'Janketti	RU2139850C1
DERIVATIVE 6-CARBONITRILE DIPYRIDOPYRROLES AND APPLICATION THEREOF IN CANCER TREATMENT	2010	Chehn' Khuehjfehn' Drobnik Dzhoj Dajk Khejzl Dzhoan Ehllvud Charl'Z Gazzard L'Juis Dzh. Gudakr Sajmon Kintts Sehmjuel' Lissikatos Dzhozef P. Makleod Kalum Uill'Jams Karen	RU2575635C2

RU 2 291 868 C2

Authors

Ehnneken Loran Fransua Andre

Stouks Ehlajn Sofi Ehlizabet

Tomas Ehndrju Piter

Dates

2007-01-20—Published

2000-11-01—Filed