FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel agent for vomiting prophylaxis in mammals and to pharmaceutical preparations based on thereof. Agent is tetrahydrobenzo[cd]indoles of the general formula (I): 
where R1 is hydrogen atom, C1-C4-alkyl or allyl; R2 is hydrogen atom, C1-C4-alkyl or allyl; R3 and R4 each independently means hydrogen atom, C1-C4-alkyl, C1-C4-alkyl substituted with phenyl group, phenyl; or R3 and R4 taken in common with nitrogen atom to which they are bound form C3-C5-heterocyclic ring at condition that one of R3 and R4 can be hydrogen atom while other of R3 and R4 must not be hydrogen atom; or its pharmaceutically acceptable acid-additive salt. Claimed agent shows the enhanced activity as compared with that of the known hexahydrobenzoindoles. EFFECT: new agent indicated above, enhanced activity. 9 cl, 4 tbl, 8 ex
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1990 |
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1992 |
- Richard Nolan Bukher[Us]
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1992 |
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1991 |
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|
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1994 |
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