FIELD: therapeutic products. SUBSTANCE: spherical or lens-shaped granules with unique maximum diameter 0.5 to 4 mm consist of, wt %: at least one biologically-active compound, 0.1-87; at least one water-insoluble polymer, 5-50; at least one lipophilic component as plasticizer for above polymer, 5-45; naturally occurred or semisynthetic polymer gel former, 0-50; and one or several standard adjuvants. Gel former is a water-soluble cellulose derivative or water-soluble polysaccharide or their mixtures. Granules are prepared by extruding molten mixture of components at 50 to 200 C involving continuous shaping. EFFECT: enabled controlled complete release of active principle according to delayed profile. 8 cl, 4 tbl
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