METHOD FOR PERFORMING NEUROPATHOLOGY SCREENING Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: method involves taking liquid sample from the first patient. It is united with antibody showing specific immunoreactivity with ICAM- 4. Quantitative analysis of ICAM-4/antibody binding is carried out in the sample. ICAM/antibody binding is compared in the sample to the like binding in the sample taken from the second patient having no neurologic disease. Cleaned and separated DNA contains promoting agent for ICAM-4 mammalians. Chimera polynucleotide has promoting agent for human ICAM-4 gene. Expression vector contains the mentioned DNA. Host cell is transformed with the expression vector. Polypeptide denoted as ICAM-4 belongs to cell adhesion factors. It possesses structural affinity to intercellular adhesion factors ICAM-1, ICAM-2, ICAM-R. EFFECT: enhanced reliability in determining levels of soluble ICAM-4. 5 cl, 5 tbl