FIELD: molecular biology, biotechnology, pharmacy. SUBSTANCE: polynucleotide encoding polypeptide-ligand flt3 is cloned to expressing vector showing functionality in mammalian cells. Polypeptide-ligand flt3 is prepared by culturing the strain cell CHO transfected with vector. Pharmaceutical composition that is able to stimulate proliferation and differentiation of cell-precursors and stem cells contains polypeptide flt3 taken in the effective amount. Invention provides the development of agents used for treatment of patients with anemia, AIDS and cancer diseases. Invention can be used for preparing ligand flt3. EFFECT: improved preparing method, valuable biological and medicinal properties of polypeptide. 18 cl, 4 tbl, 14 ex
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