POLYPEPTIDE WITH PHOSPHODIESTERASE ENZYMATIC ACTIVITY Russian patent published in 2006 - IPC C12N15/55 C12N9/16 G01N33/68 C07K16/40 C12Q1/68

Abstract RU 2272841 C2

FIELD: genetic engineering, biotechnology, biochemistry, medicine.

SUBSTANCE: invention represents a polypeptide of new family of phosphodiesterases and a polynucleotide encoding thereof. Invention relates to the development of methods for detecting partners in specific binding indicated polypeptide and polynucleotide involving stages for their contacting with a compound, detection for binding and detection a compound as a partner for specific binding. Also, invention proposes the constructed expression construction that is used in the method for preparing polypeptide of new family of phosphodiesterases for preparing a cell-producer. Also, monoclonal and polyclonal antibodies raised to this polypeptide have been prepared. Invention describes anti-sense polynucleotide for regulation of expression of polypeptide of new family of phosphodiesterases. Using the invention provides additional pharmacological approaches in treatment of states associated with disturbance of metabolic ways of cyclic nucleotides.

EFFECT: valuable medicinal and biochemical properties of polypeptide.

27 cl, 3 tbl, 11 ex

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RU 2 272 841 C2

Authors

Lokni Kejt

Dates

2006-03-27—Published

1998-10-16—Filed