FIELD: organic synthesis. SUBSTANCE: novel derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid described by general formula I: 
(I), wherein R1 and R3, identical of different, are C1-C8-alkyl optionally substituted by C1-C6-alkoxy or hydroxyl, and R2 is phenyl optionally substituted by halogen or cyano group. Preparation procedure I: benzylidene compound of formula II: 
(II) is brought into interaction with aminocrotonic acid ester III: 
(III), in which R1 and R2 are defined as indicated above and A is benzyl, in inert solvent, optionally in presence of base. Resulting intermediate is cleaved to liberate malic acid imide and desired product is isolated in the form of free base or salt. Preparation procedure II: benzylidene compound of formula IIa: 
(IIa) is brought into interaction with aminocrotonic acid ester IIIa: 
(IIIa), in which R1, R2, and A are defined as indicated above and synthesis is further continued as described for preparation procedure I. Compounds I are Ca(II) antagonists and show favorable effect on learning capacity and memory function. EFFECT: expanded assortment of useful biologically-active compounds. 5 cl, 2 dwg, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF 1,4-DIHYDROPYRIDINE, MIXTURES OF THEIR ISOMERS OR SEPARATE ISOMERS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND 2-CHLORO-3-CYANOBENZALDEHYDE | 1994 |
|
RU2155751C2 |
| 1,4-FIHYDROPYRIDINE DERIVATIVES WITH CYCLIC BRIDGE IN POSITIONS 1,2 IN THE FORM OF MIXTURE OF THEIR ISOMERS | 1995 |
|
RU2155765C2 |
| DIHYDROPYRIDINE DERIVATIVES, MIXTURE OF THEIR ISOMERS, INDIVIDUAL ISOMERS OR THEIR PHYSIOLOGICALLY TOLERANTABLE SALTS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND METHOD OF THEIR SYNTHESIS | 1992 |
|
RU2081872C1 |
| DERIVATIVES OF 4-ARYL-6-AMINONICOTINIC ACID AND THEIR SALTS | 1995 |
|
RU2154635C2 |
| 0 |
|
SU516352A3 | |
| METHOD OF PREPARING 1,4-DIHYDROPYRIDINECARBOXYLIC ACID ARALALKYL ESTERS | 0 |
|
SU574150A3 |
| 1-ALKYL-3,5-DIALYL-1,4-DIHYDROPYRIDINE DERIVATIVES AS MIXTURE OF ISOMERS THEREOF | 1995 |
|
RU2158259C2 |
| DERIVATIVES OF PYRIDOBENZOXADIAZINE CARBOXYLIC ACID, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS, THEIR PHARMACEUTICALLY USED HYDRATES AND SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY ON THEREOF | 1995 |
|
RU2138504C1 |
| 4H-PYRAN DERIVATIVES, MIXTURE OF ISOMERS THEREOF, INDIVIDUAL ISOMERS AND SALTS THEREOF | 1996 |
|
RU2164915C2 |
| DERIVATIVES OF PYRIDOBENZOXADIAZINE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS, THEIR HYDRATES AND SALTS | 1994 |
|
RU2131430C1 |
