AGENT IN COSMETIC OR PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISORDERS ASSOCIATED WITH SUPERREGULATION OF RRA RECEPTORS AND/OR HYPERVITAMINOSIS A, AND COMPOUNDS EXHIBITING THIS ACTIVITY Russian patent published in 2000 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides retinoid- type agent corresponding to general formula I: (I), wherein R₁ is methyl, hydroxymethyl, radical -O-R₃, or radical -CO-R₄; R₂ is one of the radicals -(X)-(CH₂)_q-R₆, -(X)_n-(CH₂)_q-R₇, -CH=CH-(CH₂)₃-R₆, or -CH=CH-(CH₂)_t-R₇; Ar is radical depicted by formulas II (a-d): (II); in which definition, in turn, R₃ is hydrogen atom, lower alkyl, or radical -(CH₂)_m-(CO)_n-R₈; R₄ is hydrogen atom, lower alkyl, amino radical of the formula -NR'R", or radical OR₉; R₅ is hydrogen or halogen atom, linear or branched C₁-C₂₀-alkyl, hydroxyl, radical -OR₁₀ or OCOR₁₀; R₆ is hydrogen atom, linear or branched C₁-C₂₀-alkyl, or alkenyl; R₇ is aryl, mono- or polyhydroxylic radical, in which hydroxyl groups are optionally protected by methoxy or acetoxy groups or by radical -COR₄, provided that R₇ is not polyether radical containing oxygen atom in alpha position to carbon atom in sixth position of naphthyl radical; R₈ is lower alkyl or saturated heterocyclic radical; R₉ is hydrogen, linear or branched C₁-C₂₀- alkyl, alkenyl, mono- or polyhydroxyalkyl, aryl, or arylalkyl radical optionally substituted by a sugar, amino acid or peptide residue; R_10/ is lower alkyl; X is oxygen atom or -S(O)₂ radical; R' and R", identical or different, are hydrogen atom, lower alkyl, mono- or polyhydroxyalkyl optionally substituted by aryl radical, amino acid, peptide or sugar residue, or R' and R" form together saturated heterocycle; m is integer from 1 to 3, n is 0 or 1; p integer from 5 to 12, q from 0 to 12, n from 0 to 2, s from 3 to 10, and t from 0 to 10; and also salts of the above-defined compounds or their chiral analogs. EFFECT: increased assortment of drugs. 23 cl, 43 ex