NOVEL MEDICINAL FORMS OF CYCLOSPORINE FOR ORAL ADMINISTRATION HAVING SIMPLE FORMULATION AND BIOAVAILABILITY, AND METHOD OF PREPARATION THEREOF Russian patent published in 2000 - IPC

FIELD: transplantation medicine. SUBSTANCE: invention aims to suppress rejection of transplants after transplantation of marrow and treatment of autoimmune diseases such as psoriasis, inflammation of uveal tract of eye, nephrotic syndrome, etc. Medicinal form of invention is made in the form of drinking solution or capsules. It contains 0.5-2 (preferably 1) wt parts of one or several amorphous cyclosporines (preferably cyclosporine A or G) as active ingredient, 6-9 (preferably 7.5) wt parts of one or several polyethylene glycol monoesters of saturated fatty C₁₀-C₂₂-hydroxyacids, and 1-3 (preferably 2) wt parts of one or several monoatomic or polyatomic alcohols as cosolvents. Preparation procedure: 100 g of amorphous cyclosporine is dissolved in 127 ml of ethanol at room temperature, after which 96 ml of propylene glycol and 750 g of above-indicated esters are added at stirring until transparent viscous solution is formed. Solution is then packaged as drinking solution or into capsules. EFFECT: achieved transparency and stability of solution after dilution with water over period of several months. 3 cl, 2 ex