FIELD: natural organic compounds. SUBSTANCE: invention relates to 14-substituted marcfortines of the general formula (I) 
or their pharmaceutically acceptable salts or 12-N-oxide where m = 0; Z, Y - oxygen atom; R1 - H, C2-7-alkanoyl or -C(O)NR4N5; R4 and R5 in common with nitrogen atom to which they are bound form morpholine ring; R14a - hydrogen atom, hydroxyl or C1-7-alkyl; R14b - H or hydroxyl; R18 - alkyl; R15a, R15b, R24, R25 - hydrogen atom. Compounds of the formula (I) are strong gerquamidaparasitic agents for endo- and ectoparasites control, in part, parasitic worms and Arthropoda causing multiple sicknesses in human, animals and plants. EFFECT: strong antiparasitic activity of compounds. 10 cl, 1 tbl, 7 dwg, 16 ex
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