DELIVERY OF NUCLEIC ACIDS Russian patent published in 2000 - IPC

FIELD: biotechnology, more particularly of nucleic acids into cells. SUBSTANCE: in order to deliver nucleic acids, cell is maintained with compound having formula: w...x-y-NH-CR₄(CH₂OR₁)(CH₂OR₂) wherein w is nucleic acid, x is peptide of amino acid, y is linker having chain which is equivalent to 1-20 carbon atoms or is not existent; R₄ is H or CH₂O-R₃, and R₁,R₂ and R₃ are identical or different and are either hydrogen, methyl, ethyl, hydroxy or acyl, group prepared from fatty acid having carbon chain containing 3-24 saturated or unsaturated carbon atoms provided that at least one radical R₁, R₂ and R₃ is acyl group prepared from fatty acid or compound of formula (2): w...x-yNHCH₂CH₂OR₅, wherein w is nucleic acid, x is peptide or amino acid, y is linker having chain which is equivalent to 1-20 carbon atoms, or it not existent, R₅ is acyl group prepared from fatty acid having carbon chain containing 3-24 saturated or unsaturated carbon atoms. Invention makes it possible to deliver gene therapeutic drug into cells. EFFECT: more efficient of nucleic acids. 44 cl, 40 dwg, 4 tbl