FIELD: molecular biology, virology. SUBSTANCE: invention relates to the purified proteins of human papilloma viruses. Purified protein of capsid protein of human papilloma virus is prepared by transformation of yeast cells with recombinant DNA molecule encoding the protein taken among the group including HPV6a, HPV11, HPV16, protein L1, protein L2, protein L1 + L2. Transformed cells are cultured under conditions providing expression of recombinant DNA molecules to obtain the crude protein composition. Papilloma virus protein is purified on chromatography column with resin PORIS. Invention ensures to develop and commercialize prophylactic and therapeutic vaccine against infection and disease induced by human papilloma virus. EFFECT: improved method of purification and preparing papilloma virus proteins. 11 dwg, 38 ex
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