FIELD: chemistry.
SUBSTANCE: strain is obtained by introducing into yeast cells a DNA sequence which codes the capsid protein L1 of HPV type 18 under control of a DAK gene promoter. The present invention provides high output of the recombinant protein L1 of HPV type 18 using simple methods of obtaining high-density cultures and can be used in microbiological synthesis of recombinant protein L1 of HPV type 18, having immunogenic properties of natural protein.
EFFECT: simple method.
5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 18 | 2014 |
|
RU2546242C1 |
| RECOMBINANT VACCINE FOR PREVENTION OF HUMAN PAPILLOMAVIRUS INFECTION AND METHOD OF ITS PREPARATION | 2014 |
|
RU2546243C1 |
| METHOD OF OBTAINING A RECOMBINANT VACCINE FOR PREVENTION OF HUMANPAPILLOMA VIRUS INFECTION, RECOMBINANT VACCINE | 2018 |
|
RU2681174C1 |
| PICHIA ANGUSTA RECOMBINANT YEAST STRAIN - PRODUCER OF CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 16 | 2011 |
|
RU2445357C1 |
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 56 | 2014 |
|
RU2546240C1 |
| RECOMBINANT YEAST STRAIN HARSENULA POLYMORPHA - PRODUCER OF THE MAIN CAPCID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 11 | 2018 |
|
RU2676160C1 |
| RECOMBINANT YEAST STRAIN HANSENULA POLYMORPHA PRODUCING THE MAIN CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS TYPE 6 | 2018 |
|
RU2675471C1 |
| RECOMBINANT STRAIN OF YEAST Hansenula polymorpha - PRODUCER OF MAJOR CAPSID PROTEIN L1 OF HUMAN PAPILLOMAVIRUS OF TYPE 16 | 2014 |
|
RU2546241C1 |
| OPTIMISED EXPRESSION OF HPV 58 L1 IN YEAST | 2004 |
|
RU2370538C2 |
| RECOMBINANT Hansenula polymorpha YEAST STRAIN - PRODUCER OF MUTANT HEPATITIS B VIRUS SURFACE ANTIGEN (VERSIONS) | 2015 |
|
RU2586513C1 |
