FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to (1R, 5S, 6S)-6-[(1R)-1-hydroxy-ethyl]-1-methyl-2-[(2S,4S)-2-[(3R)-3-methylaminomethyl-pyrrolidine-1-yl-carbonyl] -pyrrolidine-4-yl-thio] -1-carbapen- 2-ene-3-carboxylic acid or its pharmaceutically acceptable salts, pharmaceutical composition based on thereof and method of treatment. 1-Methylcarbapenem of assigned structure shows antibacterial activity in combination with low nephrotoxicity, it is not inactivated by beta-lactamase and dehydropenta-hydrase in body and not accumulated in kidneys. EFFECT: improved method of prophylaxis and treatment, valuable medicinal properties. 4 cl, 5 tbl, 61 ex
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Year |
Author |
Number |
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1996 |
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2000 |
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|
RU2214411C2 |
| CARBOPENEM DERIVATIVES AND A METHOD OF THEIR SYNTHESIS |
1993 |
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|
SU1501922A3 |
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2001 |
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2001 |
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- Atsumi Kunio
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1993 |
- Majkl Dzhon Betts
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| PEPTIDE COMPOUNDS AND METHOD OF PREPARING THEREOF |
1993 |
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| USE OF DERIVATIVES OF 1-METHYLCARBOPENEM SHOWING ANTIBACTERIAL EFFECT WITH RESPECT TO HELICOBACTER PYLORI, COMPOSITION CONTAINING 1-METHYLCARBOPENEM DERIVATIVES AS ACTIVE COMPONENT AND METHOD OF PROPHYLAXIS AND TREATMENT OF INFECTIOUS DISEASE |
1997 |
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| CRYSTALLINE PIVALOYLHYDROXYMETHYL-(1R, 5S, 6S)-[(4R)-2-OXO-4--PYRROLIDINYLTHIO]-6-[(1R)-1-HYDROXYETHYL]-1-METHYL-1-CARBAPE--NE-2-EME-3-CARBOXYLATE AND METHOD OF ITS SYNTHESIS |
1993 |
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