METHOD OF ANTIGEN-SPECIFIC SUPPRESSION OF ANTIBODY PRODUCTION USING MAGNOSORBENT Russian patent published in 2001 - IPC

FIELD: medicine, biotechnology. SUBSTANCE: method is based on the use of granulated magnosorbent based on tris-acrylic gel that is bound with human IgG by covalent way. Used magnosorbent is based on granulated tris-acrylic gel prepared by method of emulsion polymerization of N-acryloyl-2-amino-2-hydroxymethyl-1,3-propanediol and using N,N-diallyl-tartradiamide as a cross-linking agent. Immobilization of antigens is carried out at 50-60 C. Obtained magnosorbent granules have regular spheric form (diameter is 40-80 mcm) containing iron (III) oxide as magnetic matter and DNA antigen. Method provides to attain the specific absence of response in immunized animals in repeated immunization with native DNA and eliminates ricochet phenomenon that is observed in control group after extracorporal elimination of anti-DNA. Invention can be used in rheumatology and clinical immunology. EFFECT: improved method of suppression, improved properties of magnosorbent. 1 tbl, 3 ex