FIELD: organic synthesis. SUBSTANCE: invention provides oligopeptides with 6 to 100 amino acid residues, which is recognizable and destructible by free specific prostate antigen in active enzyme form, and also assays, in which indicated oligopeptides can be involved in vitro and in vivo to estimate protease activity of specific prostate antigen. Invention also discloses therapeutic agents containing conjugates of these oligopeptides represented by general formula I: (I) with known cytochemical agents. EFFECT: extended assortment of biologically-active polypeptides. 23 cl, 13 dwg, 1 tbl, 10 ex
Authors
Dates
2001-02-10—Published
1995-06-07—Filed