DERIVATIVES OF AMINO ACID, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF SUPPRESSION OF MULTIDRUG RESISTANCE Russian patent published in 2001 - IPC

Abstract RU 2165410 C2

FIELD: organic chemistry, amino acids, pharmacy. SUBSTANCE: invention describes novel compounds of the formula (I) where B and D mean hydrogen atom independently each of other and Ar means (C1-C6)-alkyl with linear or branched chain; R1 is (C1-C6)-alkyl with linear or branched chain or Ar is substituted (C1-C6)-alkyl with linear or branched chain; J means (C1-C6)-alkyl with linear or branched chain; K means (C1-C6)-alkyl with linear or branched chain, phenyl-substituted (C1-C6)-alkyl with linear or branched chain where phenyl can be substituted with halogen atom; X means phenyl substituted with O-(C1-C6); Ar means phenyl or Ar is heterocyclic aromatic group taken among the group including: 2-pyridyl, 3-pyridyl, 4-pyridyl and imidazolyl group being Ar can be substituted with halogen atom that can be used for suppression of multidrug resistance. Invention describes also method of their synthesis, pharmaceutical composition and method of suppression of multidrug resistance. EFFECT: improved method of synthesis, valuable pharmacological properties. 11 cl, 3 tbl, 25 ex

Similar patents RU2165410C2

Title Year Author Number
DERIVATIVES OF 1-(2-OXOACETYL)-PIPERIDINE- OR PYRROLIDINE-2-CARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, METHOD OF SYNTHESIS 1993
  • Dehvid M. Armistid
  • Dzheffri O. Saunders
  • Dzhoshua S. Boger
RU2158258C2
METHODS AND COMPOSITIONS FOR GROWTH STIMULATION OF NEURITIS 1996
  • Armistid Dehvid M.
RU2197240C2
SULFONEAMIDE INHIBITORS OF HIV-ASPARTYLPROTEASE, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT, METHOD OF INHIBITOR IDENTIFICATION 1993
  • Rodzher D.Tang
  • Mark A.Marko
  • Govinda Rao Bkhisetti
RU2135496C1
PHARMACEUTICAL COMPOSITION CONTAINING LACTIC ACID BUTYRATE PRODRUG 1996
  • Rodzher D. Tang
  • Bikvin Li
RU2175967C2
DERIVATIVES OF 3-[2-(3-ACYLAMINO-2-OXO-2H-PYRIDIN-1-YL)-ACETYLAMINO]-4-OXO-PENTANE ACID AND THEIR APPLICATION AS CASPASE INHIBITORS 2005
  • Sharr'E Zhan-Dam'En
  • Negtel Ronal'D
  • Mortimor Majkl
  • Stadli Dzhon R.
RU2412936C2
SERINE PROTEASE INHIBITORS 2006
  • Lajonz Stiv
  • Perni Robert B.
RU2441020C2
BENZIMIDAZOLES USED AS PROTEIN KINASE INHIBITORS 2006
  • Binch Khehjli
  • Mortimor Majkl
  • Robinson Dehniel
  • Stamos Din
  • Ehverit Sajmon
RU2415853C2
2-UREIDO-6-HETEROARYL-3N-BENZIMIDAZOLE-6-CARBOXYLIC ACID DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND/OR TOPOISOMERASE INHIBITORS FOR BACTERIAL INFECTION TREATMENT 2003
  • Charifson Pol
  • Dejnindzher Dehvid D.
  • Dramm Dzhozef
  • Grijo Ann-Lor
  • Liao Jusheng
  • Oliver-Shaffer Patritsija
  • Stamos Din
RU2333208C2
PEPTIDE KETONES, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF INTERLEUKIN-1β PROTEASE ACTIVITY 1994
  • Roland I.Dolli
  • Todd L.Grejbill
  • Gehri Dzh.Spejr
  • Kehterin P.Prouti
  • Stejnli Dzh.Shmidt
RU2133251C1
CASPASE INHIBITOR PRODRUGS 2006
  • Darrant Stiven
  • Sharr'Er Zhan-Dam'En
  • Stadli Dzhon
RU2427582C2

RU 2 165 410 C2

Authors

Robert E. Zelle

Mehtt'Ju V. Kharding

Dates

2001-04-20Published

1995-11-13Filed