2-UREIDO-6-HETEROARYL-3N-BENZIMIDAZOLE-6-CARBOXYLIC ACID DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND/OR TOPOISOMERASE INHIBITORS FOR BACTERIAL INFECTION TREATMENT Russian patent published in 2008 - IPC C07D401/04 C07D403/04 C07D401/14 A61K31/4439 A61K31/506 A61K31/444 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention describes a compound of the formula I or its pharmaceutically acceptable salt, where: Q is -NH- or -O-; W is C-R⁴; X is CH; R¹ is 5-6-membered aryl ring with 1-3 nitrogen atoms, where: R¹ is substituted by 0-3 groups selected independently out of R, oxo, or OR'; each R' is selected independently out of hydrogen atom or C_1-4aliphatic group; R² is selected out of hydrogen atom or C_1-3aliphatic group; R³ is selected out of C(O)NHR, C(O)N(R)₂, C(O)R, CO₂R, C(R')=NOR or C(R')=NOH; each R is selected independently out of T-Ar or C_1-6aliphatic group, where: the said C_1-6aliphatic group is substituted by 0-3 groups selected independently out of R' or OR'; T is (CH₂)_y, where y is 0, 1 or 2; Ar is selected out of: (a) 3-8-membered saturated, non-saturated or aryl ring; (b) 3-7-membered heterocyclic ring with 1-3 nitrogen atoms; or (c) 5-6-membered heteroaryl ring with 1-3 nitrogen atoms, where: Ar is substituted by 0-3 R' groups; and R⁴ is selected out of hydrogen or fluorine atoms. The invention also describes a composition for bacterial gyrase or toposiomerase IV activity inhibition, method of bacterial gyrase or toposiomerase IV activity inhibition, method of bacteria quantity reduction for patients suffering from nosocomial and non-nosocomial bacterial infections. The invention also concerns a method of obtaining the claimed compounds.

EFFECT: obtaining new compounds with useful biological properties.

23 cl, 4 tbl, 24 ex