DERIVATIVES OF ISOXAZOLE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of isoxazole of the general formula (I) where R¹ means optionally substituted C₆-C₁₄-aryl-group or 5-6-membered heterocyclic group having one heteroatom taken among nitrogen, oxygen, sulfur; R² means hydrogen, halogen atom, optionally substituted C₁-C₆-alkyl group, C₂-C₆-alkenyl group, C₂-C₆-alkynyl group, C₃-C₁₀-cycloalkyl group, C₃-C₁₀-cycloalkenyl group, cyano-group, carboxyl-group, C₁-C₇-alkanoyl-group, C₂-C₇-alkoxycarbonyl-group or optionally substituted carbamoyl-group; R³ means optionally substituted amino-group or saturated 5-6-membered heterocyclic group containing nitrogen atom; X means oxygen or sulfur atom; n means the whole number from 2 to 6, and their pharmaceutically acceptable salts. Invention relates to also pharmaceutical composition showing inhibitory activity with respect to monoaminooxidase type A and containing compound of the formula (I) or its pharmaceutically acceptable salt and pharmaceutically acceptable carrier. EFFECT: new isoxazole derivatives indicated above, valuable biochemical properties. 28 cl, 2 tbl, 107 ex