HETEROCYCLIC COMPOUND Russian patent published in 2010 - IPC C07D413/14 A61P19/02 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a group of novel chemical compounds pharmacologically acceptable salts thereof having formula , where A represents COOH; B represents H; n equals 0; V represents -CH₂-, a single bond; W represents a 5-7-member heteroaromatic group with one heteroatom selected from N, O, S which can optionally be substituted with 1-3 substitutes selected from a group of substitutes A, when V represents a -CH₂-group, where if V represents a single bond, W represents a bicyclic condensed a ring -member heterocyclic group with one heteroatom selected from O, S, which can optionally be substituted with 1-3 substitutes selected from a group of substitutes A; X represents a 5-7-member heteroaromatic group with one O atom and one or two N atoms, which can optionally be substituted with 1-3 substitutes selected from a group of substitutes A; Y represents C₆-C₁₀ aryl which can optionally be substituted with 1-3 substitutes selected from a group of substitutes A, a 5-7-member heteroatomatic group with one S atom which can optionally be substituted with 1-3 substitutes selected from a group of substitutes A; Z represents C₁-C₈ alkyl, C₃-C₇ cycloalkyl which can optionally be substituted with 1-5 substitutes selected from a group of substitutes A; C₆-C₁₀ aryl which can optionally be substituted with 1-5 substitutes selected from a group of substitutes A; C₆-C₁₀ aryloxy which can optionally be substituted with 1-5 substitutes selected from a group of substitutes A, or C₁-C₁₂ aralkyl which can optionally be substituted with 1-5 substitutes selected from a group of substitutes A; group of substitutes A represents halogen, C₁-C₆ alkyl, halogen C₁-C₆ alkyl, C₁-C₆ alkoxy.

EFFECT: compounds exhibit inhibitory activity towards HvGR which enables their use to prepare a pharmaceutical composition used in therapy for autoimmune diseases.

33 cl, 6 tbl, 30 ex