Patenton — panteon of patents

(19)

RU

(11)

2 165 926

(13)

C2

(51)

IPC

(21) (22)

Application

98120918/04, 1998-11-25

(24)

Start date

1998-11-25

(22)

Actual filing date

1998-11-25

(45)

Published

2001-04-27

(72)

Inventor

Krivonogov V.P.Plechev V.V.Alekhin E.A.Lazareva D.N.Timerbulatov V.M.Junusov M.S.Myshkin V.A.Evsjukov A.A.

(73)

Holder

Plechev Vladimir VjacheslavovichKrivonogov Viktor Petrovich

2-METHYL-4-AMINO-6-HYDROXYPYRIMIDINE AND METHODS OF ITS SYNTHESIS (VARIANTS) Russian patent published in 2001 - IPC

Abstract RU 2165926 C2

FIELD: organic chemistry, heterocyclic compounds, chemical technology. SUBSTANCE: invention relates to the novel 2-methyl-4-amino-6-hydroxypyrimidine of the formula (I) and methods of its synthesis. The first method of synthesis involves mixing cyanoacetic ester 1-acetamidine hydrochloride in methanol and sodium methylate followed by separation of precipitated NaCl, methanol distillation off, precipitate dissolving in water and acidification with acetic acid. The second method involves addition of mixture of acetamidine hydrochloride, acetic ester and absolute methanol to sodium methylate by drops at 10-5 C for 1-5 h followed by distillation off of methanol, precipitate dissolving in water and acidification with acetic acid. Proposed compound shows immunotropic activity and can be used in medicine. EFFECT: new compound indicated above, improved methods of synthesis. 4 cl, 2 tbl, 4 ex

Similar patents RU2165926C2

Title Year Author Number
PYRIMIDINE ACYCLONUCLEOSIDES SHOWING IMMUNOTROPIC AND ANTIINFLAMMATORY ACTIVITY 1992
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Davydova V.A.
  • Ismagilova A.F.
  • Sakhautdinova G.M.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
  • Krivonogova I.I.
 RU2051150C1
1,3(2,6-DIHYDROXY-4-THIAHEPTAMETHYLENE-6-METHYLURACIL HAVING IMMINOTROPIC AND ANTIINFLAMMATORY ACTIVITY 1992
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Davydova V.A.
  • Ismagilova A.F.
  • Sakhautdinova G.M.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
  • Krivonogova I.I.
 RU2034839C1
BIS- [2,4- DIOXO-6- METHYL -1,2,3,4- TETRAHYDROPYRIMIDINE -3- (5-MET- HYL-3-THIAHEXYL) -S] -CIS- DICHLOROPLATINUM SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Krivonogov V.P.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
 RU2035467C1
1,3-BIS-(ISOBUTYLTHIOETHYL) -5-ISOBUTYLTHIOETHYLHYDROXY -6-METHYLURACIL SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
 RU2027710C1
1,3-BIS-(ISOBUTYLTHIOETHYL)-5-HYDROXY-6-METHYLURACIL SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
 RU2028296C1
1,3-BIS-(ISOBUTYLTHIOETHYL)-6-METHYLURACIL SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
 RU2028295C1
5-HYDROXY-3,6-DIMETHYLURACIL SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Kukovinets A.G.
  • Ismagilova A.F.
  • Volkova S.S.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
 RU2035455C1
3-ISOBUTYLTHIOETHYL-6-METHYLURACIL SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Krivonogov V.P.
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
  • Spirikhin L.V.
  • Abdrakhmanov I.B.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
 RU2035456C1
(2,4- DIOXO -1,3-BIS - (5- METHYL -3- THIAHEXYL)-6-METHYL- 1,2,3,4- TETRAHYDROPYRIMIDINE -S,S) -CIS - DICHLOROPLATINUM SHOWING IMMUNOTROPIC ACTIVITY 1991
  • Tolstikov G.A.
  • Murinov Ju.I.
  • Krivonogov V.P.
  • Afzaletdinova N.G.
  • Khisamutdinov R.A.
  • Zarudij F.S.
  • Lazareva D.N.
  • Ismagilova A.F.
  • Volkova S.S.
 RU2028300C1
DERIVATIVES OF 4-OXO-1,4-DIHYDROPYRIMIDINE SHOWING IMMUNOSTIMULATING ACTIVITY 1992
  • Oganesjan Eh.T.
  • Kodonidi I.P.
  • Rjabukhin Ju.I.
  • Guteneva G.S.
  • Makarov V.A.
  • Sizjakina L.P.
 RU2037491C1

RU 2 165 926 C2

Authors

Krivonogov V.P.

Plechev V.V.

Alekhin E.A.

Lazareva D.N.

Timerbulatov V.M.

Junusov M.S.

Myshkin V.A.

Evsjukov A.A.

Dates

2001-04-27—Published

1998-11-25—Filed

read Similar patents