FIELD: medicine. SUBSTANCE: method involves determining general lacrimal fluid immunoglobulin G activity, general proteolysis α1- inhibitor activity (α1-PI) by calculating prediction coefficient from formula PK= General IgG activity / General α1-PI activity. Growth of the value is interpreted in terms of purulent cornea ulcer progress. PC being from 3.2± 0.2 to 12.5 ± 0.3, favorable disease development is to be predicted. The PC value being from 13.0 ± 0.1 to 17.8 ± 0.2, cornea perforation is to be predicted. EFFECT: high accuracy of early stage prediction of purulent cornea ulcer development.
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