SUBSTITUTED CARBOXAMIDES AND PHARMACEUTICAL COMPOSITION ON SAID Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the substituted carboxamides of the formula (I) where R¹ - mercapto-, acetylthio-, carboxy-, hydroxycarbamoyl-, C_1-4-alkoxycarbonyl-, ar-(C_1-4)-alkoxycarbonyl-, benzylhydroxy- -carbamoyl-group or -PO(OH)-CH₂SR⁶ where R⁶ means quinolyl-, naphthyl-, pyridyl- or phenyl-group; R² means alkyl, cycloalkyl-C_1-4-alkyl or aralkyl; R³ means cycloalkyl-C_1-4-alkyl possibly substituted with hydroxy-, alkylthio-, pyridyl or indolyl-group; R⁴ means nitro-, amino-, cyano-, hydroxy-, alkoxy-, alkoxycarbonylalkyl-, tetrazolyl-, carbamoyl-group; R⁴ - hydrogen atom or hydroxy-group as a separate stereoisomer or their mixture, or its pharmaceutically acceptable salt that show capability to inhibit activity of matrix metalloproteases. EFFECT: improved method of synthesis, inhibitory effect of enzyme activities. 16 cl, 32 ex