METHOD OF SYNTHESIS OF DIOXOAZABICYCLOHEXANES Russian patent published in 2000 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to synthesis of synthetic intermediate compounds used for synthesis of antibiotics. Invention describes method of synthesis of compound (I) where R means C₁-C₆-alkyl, C₁-C₆-cycloalkyl or benzyl and where phenyl moiety of indicated benzyl group is substituted with one or some substituents and each of the latter is taken independently among the group including halogen atom, nitro-group, C₁-C₆-alkyl, C₁-C₆-alkoxy-group, amino-group or trifluoromethyl-group. Method of synthesis involves the following stages. Solution containing compound of the formula (II) , halogennitromethane and organic solvent taken among acetone, dimethylformamide, dimethylacetamide, acetonitrile, dimethylsulfoxide, N-methyl-pyrrolidone and dimethoxyethane is added to mixture containing base and organic solvent. Indicated organic solvent as indicated above and indicated base taken among potassium carbonate, cesium carbonate, trisodium phosphate and potassium fluoride to synthesize compound of the formula (I) and any excess of base is removed from reaction mixture before isolation of compound (I). EFFECT: increased yield of end compounds. 22 cl, 1 tbl, 18 ex