FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: invention relates to acetylene aminoalcohols of the formula (I) 
that are able to exhibit effective antagonistic effect with respect to toxic effects of haloperidol in experiments with daphnia at their low own toxicity for this animals. Owing to, these compounds can be used in medicine for treatment and prophylaxis of parkinsonism. EFFECT: valuable medicinal properties of compounds. 1 tbl, 1 ex
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|---|---|---|---|
| HYDROCHLORIDES OF SUBSTITUTED ACETYLENIC AMINOALCOHOL-ACTIVE AND LOW-TOXIC HALOPERIDOL ANTAGONISTS | 1999 |
|
RU2174510C2 |
| AMINOALCOHOLS OF ACETYLENE ORDER SHOWING EXPRESSED M-CHOLINO-LYTIC PROPERTY AND WEAKLY SUPPRESSING CENTRAL NERVOUS SYSTEM | 1998 |
|
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| 1-PHENYL-1-CYCLOPENTYL-4-PIPERIDINO-2 BUTIN-1-OLA HYDROCHLORIDE POSSESSING ACTIVITY IN TREATING AND PREVENTING PARKINSONISM | 1998 |
|
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| USING 1-PHENYL-1-(1'-METHYLCYCLOPENTYL)-4-PIPERIDINO-2-BUTYNE-1-OL HYDROCHLORIDE AS AGENT POSSESSING M1 CHOLINE-BLOCKING ACTIVITY | 2004 |
|
RU2273478C2 |
| THERAPEUTIC COMPOSITION AND MEDICINAL FORM BASED THEREON | 2015 |
|
RU2629314C2 |
| KAPPA-OPIOID AGONIST | 2009 |
|
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| MEDICATIONS EXHIBITING PROPERTIES OF ANTAGONISTS OF SEROTONIN 5-HT- RECEPTORS | 2011 |
|
RU2465901C2 |
| ARYLHYDRAZONES 5,6,7,8-TETRAHYDROQUINOLINEDIONES-2,5 POSSESSING CARDIPTONIC ACTIVITY | 1991 |
|
RU2009129C1 |
| ANTICONVULSIVE PREPARATIONS | 1994 |
|
RU2108094C1 |
| 1-PHENYL-1-CYCLOPENTYL-4-PIPERIDINO-2-BUTYNE-1-OL HYDROCHLORIDE (PENTIFIN) ELICITING M4 CHOLINE-BLOCKING ACTIVITY | 2002 |
|
RU2224516C1 |
