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Application

2002127885/15, 2002-10-17

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Start date

2002-10-17

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Actual filing date

2002-10-17

(45)

Published

2004-02-27

(72)

Inventor

Kosmachev A.B.Dagaev S.G.Libman N.M.Fil'Ko O.A.Khrabrova A.V.Kubarskaja L.G.Solov'Eva N.E.Dolgo-Saburov V.B.

(73)

Holder

Gosudarstvennoe Uchrezhdenie Institut Toksikologii

1-PHENYL-1-CYCLOPENTYL-4-PIPERIDINO-2-BUTYNE-1-OL HYDROCHLORIDE (PENTIFIN) ELICITING M4 CHOLINE-BLOCKING ACTIVITY Russian patent published in 2004 - IPC

Abstract RU 2224516 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes a new agent with expressed selective blocking activity with regards to muscarinic receptors of subtype M4 taking part in control over the formation of cAMP and in activation of peptides Gi/Go. Agent represents 1-phenyl-1-cyclopentyl-4-piperidino-2-butyne-1-ol (pentifin) of the formula (I) known early as an agent used in treatment of Parkinson's disease. EFFECT: valuable medicinal properties of agent, expanded assortment of agents of indicated designation. 1 tbl, 1 ex

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RU 2 224 516 C1

Authors

Kosmachev A.B.

Dagaev S.G.

Libman N.M.

Fil'Ko O.A.

Khrabrova A.V.

Kubarskaja L.G.

Solov'Eva N.E.

Dolgo-Saburov V.B.

Dates

2004-02-27—Published

2002-10-17—Filed