FIELD: medicine; pharmacology. SUBSTANCE: acyclic compounds, namely, hydrazides of diphenylacetic acid, benzylic acid and bis(o-tolyl)glycolic acid possess anticonvulsive activity. The latter as determined by maximum electroshock test is as follows, mg/kg: for compound ED5054, 31-78; for compound ED5037, 28-48; for compound ED5035, (33-38. Acute toxicity LD50 for the same compounds is, respectively, as follows, mg/kg: 520 (486-568), 740 (688-795) and 680 (621-745). EFFECT: higher efficiency. 1 tbl
| Title |
Year |
Author |
Number |
| N-ACYLMONOHYDRAZIDE OF MALEIC ACID EXHIBITING ANTICONVULSIVE ACTIVITY |
1982 |
- Andrejchikov Ju.S.
- Zalesov V.S.
- Koz'Minykh V.O.
- Dolbilkin K.V.
|
SU1053459A1 |
| HYDRAZIDE OF DI-(O-CHLOROPHENYL)-GLYCOLIC ACID DISPLAYING ANTICONVULSION ACTIVITY |
0 |
- Berdinskij I.S.
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- Andrejchikov Yu.S.
- Kozminykh V.O.
|
SU1086727A1 |
| METHOD OF SYNTHESIS OF 1,6-DIARYL-3,4-DIHYDROXY-2,4-HEXADIENE-1,6-DIONES |
1990 |
- Koz'Minykh V.O.
- Igidov N.M.
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|
SU1767835A1 |
| MALEIC ACID CYANOACETYL- OR ISOBUTYRYL HYDRAZIDE SHOWING ANTIAGGREGATIVE ACTIVITY WITH REGARD TO PLATELETS |
1991 |
- Koz'Minykh V.O.
- Syropjatov B.Ja.
|
SU1807685A1 |
| HYDRAZIDES OF DIARYLGLYCOLIC ACID DISPLAYING ANTICONVULSION ACTIVITY |
0 |
- Berdinskij I.S.
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- Zalesov V.S.
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|
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0 |
- Andrejchikov Yu.S.
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|
SU1088291A1 |
| 2-METHOXYCARBONYLMETHYLENE-4-BROMO-5-ARYL-2,3-DIHYDROFURAN-3-- ONES SHOWING ANTISTAPHYLOCOCCUS ACTIVITY |
1987 |
- Koz'Minykh E.N.
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- Koz'Minykh V.O.
- Andrejchikov Ju.S.
|
SU1455617A1 |
| N-NITROBENZOYLHYDRAZIDE OF MALEIC ACID SHOWING ANTIAGGREGATING ACTIVITY WITH RELATION TO BLOOD PLASMA PLATELATES |
1985 |
- Andrejchikov Ju.S.
- Syropjatov B.Ja.
- Koz'Minykh E.N.
- Koz'Minykh V.O.
|
SU1340060A1 |
| METHOD OF PRODUCING 2,3-BIS-AROYLMETHYLENE-1,2,3,4-TETRAHYDROQUINOXALINES |
1991 |
- Koz'Minykh V.O.
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|
RU2009136C1 |
| METHOD FOR PRODUCING 5-ARYL-2-HYDROXY-2- (TRIPHENYLPHOSPHARANILIDENE) -METHOXYCARBOBYLMETHYL-2,3- DIHYROFURANONES |
1990 |
- Koz'Minykh V.O.
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|
RU2009144C1 |
