DERIVATIVES OF PYRIMIDINE, PHARMACEUTICAL COMPOSITION AND METHOD OF PROPHYLAXIS AND TREATMENT OF DISEASE Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel derivatives of pyrimidine or their pharmaceutically acceptable salts, pharmaceutical composition acting as an inhibitor of endothelin and method of prophylaxis and treatment of disease induced by endothelin, in part, diseases associated with circulation disorder, for example, hypertension, asthma, stenocardia and others. Derivatives of pyrimidine correspond to the general formula (I), where R¹ means hydroxyl, lower alkoxyl, phenyl-lower alkoxyl, benzylhydroxy-group or NR²R³; X means oxygen atom or NR⁴; m = 2 or 3; n = 1 or 2; R² means hydrogen atom; R³ means lower alkyl, phenylethyl, phenyl group that can be substituted with lower alkyl, lower alkoxyl, or pyridyl; R⁴ means lower alkyl group, phenyl group, formyl group or lower alkoxycarbonyl group. Pharmaceutical composition has derivative of pyrimidine of the formula (I) or its salt and a pharmaceutically acceptable carrier. Method of prophylaxis and treatment involves administration of effective amount of the compound of the formula (I) or its salt. EFFECT: new compounds indicated above, valuable medicinal properties. 9 cl, 3 tbl, 1 dwg, 27 ex