DERIVATIVES OF PYRIMIDINYLPYRAZOLE AND ANTITUMOR AGENT Russian patent published in 2000 - IPC

Abstract RU 2146675 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to the novel agent of the general formula (I) : R¹-R⁶ where preferable radicals are the following: each of R¹ and R³ means alkyl-group that can be substituted with halogen atom, amino-group, hydroxyl-group, alkoxyl-group or thiol group; hydrogen atom, halogen atom or alkoxyl-group; R³ means hydrogen atom; R⁴ means methyl-group; R⁵ means hydrogen atom or alkyl-group and R⁶ means the group of the formula: where Z is phenyl-group. Compound shows an antitumor activity. Invention relates to also the antitumor agent based on said. EFFECT: valuable pharmacological property of compound. 10 cl, 2 tbl, 42 ex

Similar patents RU2146675C1

Title	Year	Author	Number
PYRAZOLE DERIVATIVES	2004	Kanaja Naoaki Isikhara Khiroaki Kimura Euiti Isijama Takasi Otiaj Juiti	RU2332412C2
AROMATIC AMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION	1992	Takajasu Nagakhara Naoaki Kanaja Kazue Inamura Jukio Ekojama	RU2139851C1
PIPERIDINE DERIVATIVE	2008	Khigasiura Kunikhiko Ogino Takasi Ito Taidzo Ivatsuki Khirojuki	RU2475485C2
GUANIDINE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND METHOD FOR INHIBITING Na/H EXCHANGE IN CELLS	1994	Atsusi Kuno Josikazu Inou Khisasi Takasugi Khiroaki Mizuno Kumi Jamasaki	RU2141946C1
VLA-4 INHIBITORS	2001	Nakajama Atsusi Matinaga Nobuo Joneda Josijuki Sugimoto Juiti Tiba Dzun Vatanabe Tosijuki Ijmura Sin	RU2290403C2
AMINOPROPYLIDENE DERIVATIVES	2009	Khigasiura Kunikhiko Ogino Takasi Ito Taidzo Kunimasu Kodzi Furukava Kazukhito	RU2483063C2
1,2,3,4-TETRAHYDROPYRAZOLO-[5,1-C]-(1,2,4)-TRIAZINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION INHIBITING PRODUCING AN INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR, METHOD OF PROPHYLACTIC OR THERAPEUTIC TREATMENT OF PATIENTS WITH DISEASES MEDIATED BY INTERLEUKIN AND TUMOR NECROSIS FACTOR	1994	Esio Kavai Khitosi Jamazaki Khirokazu Tanaka Teruo Oku	RU2124517C1
DIAZABICYCLOALKENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION	1993	Tetsua Mimura Khideo Kubo	RU2126008C1
DERIVATIVES OF ANTHRANILIC ACID OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, INTERMEDIATE COMPOUNDS USED FOR THEIR SYNTHESIS AND DRUG	1994	Fumikhiro Ozaki Kejdzhi Isibasi Khironori Ikuta Khiroki Isikhara Sigeru Souda	RU2128644C1
TETRAHYDROCARBOLINE DERIVATIVE	2011	Okhata Akira Nakatani Singo Sugijama Tetsuja Morimoto Takasi	RU2572818C2

RU 2 146 675 C1

Authors

Akio Edzima

Masamiti Sugimori

Ikuo Mitsui

Dates

2000-03-20—Published

1995-09-25—Filed