CYCLIC AMINE COMPOUNDS Russian patent published in 2007 - IPC C07D401/14 C07D401/06 C07D401/12 C07D405/12 A61K31/4545 A61K31/4439 A61K31/4468 A61P9/10 A61P11/06 A61P29/00 A61P37/08 A61P43/00 

Abstract RU 2299207 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of cyclic amine of the general formula (1): , their pharmaceutically acceptable salts or hydrates wherein each among R1, R2 and R3 represents independently hydrogen atom, halogen atom, hydroxy-group, (C1-C8)-alkoxy-group; each among W1 and W2 represents independently nitrogen atom (N) or -CH; X represents oxygen atom (O), -NR4, -COONR4 or -NR4CO; R4 represents hydrogen atom, (C1-C8)-alkyl, (C3-C6)-alkynyl, substituted or unsubstituted phenyl, unsubstituted benzyl, unsubstituted indanyl wherein substitute(s) of phenyl represent(s) 1-3 groups or atoms chosen from (C1-C8)-alkyl, (C1-C8)-alkoxy-group, (C1-C8)-alkoxy-group substituted with 1-3 halogen atoms, (C1-C8)-alkylthio-group, (C1-C8)-alkylsulfonyl, halogen atom, trifluoromethyl group and (C1-C3)-alkylenedioxy-group; each among l, m and n represents number 0 or 1. Proposed compounds possess inhibitory effect on cell adhesion and/or cell infiltration and can be used as a medicinal agent and pharmaceutical composition based on thereof.

EFFECT: valuable biological and medicinal properties of compounds and pharmaceutical composition.

6 cl, 1 tbl, 439 ex

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RU 2 299 207 C2

Authors

Kodama Tatsukhiko

Tamura Masakhiro

Oda Tosiaki

Jamazaki Jukijosi

Nisikava Masakhiro

Takemura Sundzi

Doi Takesi

Kiotani Josinori

Okhkuti Masao

Dates

2007-05-20Published

2002-08-28Filed