FIELD: medicine, cardiology, biochemistry. SUBSTANCE: invention proposes a pharmaceutical composition for inhibition of activity of 3-hydroxy-3-methyl-glutaryl-CoA-reductase in mammals. This composition has effective amount of citrus fruits peel extract as an active component in combination with a pharmaceutically acceptable carrier. Food composition or drinking composition designated for inhibition of activity of 3-hydroxy-3- methylglutaryl-CoA-reductase have effective amount of citrus fruits peel extract. Use of proposed composition ensures to decrease blood plasma cholesterol level effectively. EFFECT: enhanced effectiveness of extract. 6 cl, 4 tbl, 6 ex
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