DERIVATIVES OF VITAMIN D, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 2001 - IPC

FIELD: organic chemistry, steroids, vitamins, pharmacy. SUBSTANCE: invention relates to novel derivatives of vitamin D₃ of the formula (I) where Q means methylene, ethylene, trimethylene or tetramethylene, -CH= CH-, CH= CH-CH=CH-; Y is a single bond, -CH(OH), -O-(C₆H₄)-(meta) or -S-(C₆H₄)-(meta); R₁ and R₂ are similar or different and mean methyl, ethyl or R₁ and R₂ in common with carbon atom labeled by asterisk in formula (I) and carrying group Z can form C₃H₆-carbocyclic ring; Z means hydrogen atom or hydroxy-group under condition that when Y means simultaneously -CH(OH)-, R¹ and R² are methyls, Z means hydroxy-group then configuration at C-20 cannot be R. Invention describes methods of synthesis of compounds of the formula (I). Said compounds show anti-inflammatory and immunomodulating effect and strong activity in induction of differentiation and inhibition of nondesirable proliferation of some cells. EFFECT: improved method of synthesis, valuable medicinal properties. 11 cl, 6 tbl, 18 ex