DERIVATIVES OF PROTEIN OB Russian patent published in 2002 - IPC

FIELD: medicine, proteins. SUBSTANCE: invention relates to derivative of obesity protein OB with the prolonged half-life value. Invention relates, in part, to protein OB-immunoglobulin chimeras and derivatives of polyethylene glycol of protein OB that have the prolonged half-life value as compared with the corresponding native proteins OB. Also, invention relates to methods of appetite and/or weight body decrease and treatment of patients with other physiological states using derivatives of protein OB with the prolonged half-life value. EFFECT: broadened arsenal of agents used for control of obesity. 26 cl, 33 dwg, 8 pic, 1 ex