FIELD: biotechnology, immunology, proteins.
SUBSTANCE: invention relates to immunoglobulin E (IgE), IgE-antagonists, anti-IgE antibodies able for binding with human IgE and to a method for improving polypeptides involving anti-IgE antibodies. Invention provides preparing the improved polypeptides that don't elicit not only the "inactivation" effect in izomerization reaction of aspartyl residue but elicits the affinity property to the molecule-target, for example, to antigen.
EFFECT: improved improving method, valuable medicinal and immunological properties of antibody.
16 cl, 21 dwg, 18 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL ANTI-IL13 ANTIBODIES AND USE THEREOF | 2004 |
|
RU2487887C2 |
| ANTIBODIES BINDING IL-4 AND/OR BL-13 AND THEIR APPLICATION | 2008 |
|
RU2488595C2 |
| ANTIBODIES BINDING IL-4 AND/OR IL-13, AND USE THEREOF | 2015 |
|
RU2705551C2 |
| ANTIBODIES BINDING IL-4 AND/OR IL-13, AND THEIR USE | 2015 |
|
RU2721236C2 |
| HIGHLY CONCENTRATED COMPOSITIONS OF ANTIBODIES AND PROTEINS | 2004 |
|
RU2332986C2 |
| IL-4 AND/OR IL-13 BINDING ANTIBODIES AND USING THEM | 2008 |
|
RU2580049C2 |
| FcγRIIB RECEPTOR ANTIBODIES AND APPLICATION THEREOF | 2005 |
|
RU2404991C2 |
| BACTERIUM Escherichia coli PRODUCING HETEROLOGOUS POLYPEPTIDE AND METHOD FOR PRODUCING POLYPEPTIDE | 2001 |
|
RU2287574C2 |
| ANTI-CXCR4 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES | 2014 |
|
RU2675516C2 |
| ANTIBODIES-ANTAGONISTS AGAINST Notch3 AND THEIR APPLICATION FOR PREVENTION AND TREATMENT OF Notch3-RELATED DISEASES | 2007 |
|
RU2493167C2 |
