FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, more specifically to chimeric polypeptides of fibroblast growth factors (FGF), and can be used in medicine for treating obesity, diabetes, high blood glucose, metabolic syndrome and hypercholesterinemia. What is produced is chimeric FGF19 having C-terminal portion of the hFGF19 polypeptide sequence and N-terminal portion of the hFGF21 polypeptide sequence.
EFFECT: invention enables producing the FGF19 chimeric polypeptide, which activates FGFRlc through Klotho-beta dependence, but does not substantially activates FGFR4 through either Klotho-beta independence, or Klotho-beta dependence.
18 cl, 22 dwg, 11 tbl, 15 ex
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